HIV-1 protease mutation 82M contributes to phenotypic resistance to protease inhibitors in subtype G
نویسندگان
چکیده
منابع مشابه
HIV-1 protease mutation 82M contributes to phenotypic resistance to protease inhibitors in subtype G.
OBJECTIVES The purpose of this study was the qualitative and quantitative assessment of the in vitro effect of HIV-1 protease (PR) mutation 82M on replication capacity and susceptibility to the eight clinically available PR inhibitors (PIs). METHODS The 82M substitution was introduced by site-directed mutagenesis in wild-type subtype B and G strains, as well as reverted back to wild-type in a...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2012
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dks010